New MacBook Pros powered by the M1X processor are the most anticipated, and we could also see new AirPods.
There will still be an online show, however.
A selection of digital programming will also be made available for those uncomfortable attending.
The event kicks off at 10 a.m. PT/1 p.m. ET on Apple's website.
There will be a main keynote, various developer sessions, hands-on experiences, and more.